It's starting to get interesting in the NFC. The 49ers and the Saints are both very good teams, and the season will end for one of them. I could see the game going either way, but I think it's more likely that the Saints come out on top.
Of course, I thought the Saints would easily beat the Seahawks last year in the playoffs. If you see Frank Gore eating some Skittles on the sidelines: watch out. The Saints have been known to suck at tackling physical running backs.