Of the three positions featured at the NFL Combine on Sunday (quarterback, wide receiver, and running back), only one of them should have been of significant interest for the Green Bay Packers.
James, Rainey run 4.45 40s - officially - CBSSports.com. They aren't going to use their first round draft choice on running back, but with the likely free agent departure of Ryan Grant (I haven't read a single article saying that they've even talked), they could look at using their 3rd or 4th round pick on his replacement. They need someone else because James Starks and Alex Green haven't ever made it healthy through a full 16 game season. Brandon Saine is fine, but they can stash him on the practice squad for another season. Some of the fastest running backs like LaMichael James, Cyrus Gray, Ronnie Hillman, and Chris Rainey have 3rd round grades, and one of them might be a good fit.
I have no idea what they'll do at quarterback. While they've gone with two inexperience, late round/undrafted players to back up Aaron Rodgers in recent years, they did use a 2nd round pick on Brian Brohm for a backup role (maybe Ted Thompson has learned his lesson), and they did try to sign Daunte Culpepper in 2008. Would they sign a veteran like Chad Henne if he was cheap? Will they use another high draft pick on a quarterback? My best guess is that they'll find a late round or undrafted quarterback that they can stash on the practice squad during the season, and promote Graham Harrell to the backup role.