That could be a good game because the Raiders should play better at home, and the Lions will have some problems being so far from home. This game does mark the return of Suh. The Lions have to keep winning to keep their hold on a playoff spot, and the Raiders need a win to avoid falling completely out of the playoff picture.
The only other NFC teams playing are the Eagles (hosting the Jets) and the Cardinals (hosting the Browns). The biggest game should be the Patriots at Broncos.