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Thursday Night Football, Week 1: Picking the Bills and Rams to kick off the 2022 season

The Rams are home underdogs coming off their Super Bowl win in February.

NFL: AUG 19 Preseason - Texans at Rams Photo by Brian Rothmuller/Icon Sportswire via Getty Images

The 2022 NFL season finally gets underway tonight as the reigning Super Bowl champions, the Los Angeles Rams, host the league’s first regular season game. It’s an excellent matchup, too, with the Buffalo Bills coming to town.

The Bills are preseason darlings, having won double-digit games in three straight seasons and coming off a ludicrous overtime loss to the Kansas City Chiefs in the divisional playoffs. That game will go down as one of the most incredible football games in history as the two teams combined for 78 points and nearly 1,000 total yards of offense — with 31 of those points coming after the two-minute warning in the fourth quarter.

In fact, Buffalo enters as the favorites for tonight’s game, giving 2.5 points on the road to the Rams. APC’s contributors have made our picks for tonight’s game, so let us know yours in the comments and let this serve as your game thread for the season opener.


Buffalo Bills vs. Los Angeles Rams


Thursday, September 8, 2022
5:20 PM Pacific Time (8:20 PM Eastern)


SoFi Stadium
Inglewood, California


TV Broadcast

Commentators: Mike Tirico, Cris Collinsworth, Melissa Stark

Radio Broadcast

Westwood One Sports

Online Streaming

NFL+ App and NBC Sports app


Point spread: Bills -2.5 (via DraftKings)